Human Sera
Cayman Chemical aPyroldInobutIothIophenon 50mg
A PI3KY inhibitor (IC50 0.025 UM in a binding assay) selective for PI3KY over PI3K PI3Ka and PI3KB (IC50s 7.9 10 and 1.26 UM respectively in binding assays) as well as a panel of 154 lipid and protein kinases inhibits C5a-induced phosphorylation of Akt in RAW 264.7 macrophages (IC50 1.2 UM) inhibits fMLP-induced migration of isolated human granulocytes (IC50 1 UM) decreases disease severity in a mouse model of collagen-induced arthritis at 3 and 10 mg/kg
Cayman Chemical RauwolscInhydrochlorIde 100mg
A butaprost analog with a 56-double bond and without the methyl ester
Cayman Chemical DarIfenacInhydrobromIde 50mg
Antigen human TLR9 amino acids 268-284 Host mouse clone 26C593.2 Cross Reactivity ( ) canine equine human mouse rat and Rhesus monkey TLR9 Application(s) FC (intracellular and cell surface) ICC IHC (frozen and paraffin) and WB Gene knockout experiments suggest that TLR9 acts as a receptor for unmethylated CpG dinucleotides in bacterial DNA.TLR9 is highly expressed in spleen.
Cayman Chemical ClorgylInhydrochlorIde 100mg
A dual p38a and p38B MAPK inhibitor (Kis 0.0079 and 0.025 UM respectively in cell-free assays) selective for p38a and p38B MAPK over p38Y and p38 MAPK at 10 UM inhibits LPS-induced TNF-a production in isolated rat and human PBMCs (IC50s 0.6 and 0.13 UM respectively) decreases disease severity in a mouse model of collagen-induced arthritis at 0.8-20 mg/kg improves survival normalizes blood pressure and reduces increases in plasma levels of HDL LDL and triglycerides in spontaneously hypertensive stroke-prone rats fed a high-salt high-fat diet
Cayman Chemical HydroxychloroquInsulfate 100mg
An orally bioavailable inhibitor of Smo blocks binding of BODIPY cyclopamine (IC50 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s 6-35 nM) inhibits Shh pathway activity and prevents tumor growth in cancer xenograft models
Cayman Chemical EnalaprIlathydrate 100mg
RORY Reporter Cells are prepared using INDIGOs proprietary CryoMite process. This cryo-preservation method yields high cell viability post-thaw and provides the convenience of immediately dispensing healthy division-competent reporter cells into assay plates. There is no need for intermediate spin-and-wash steps viability determinations or cell titer adjustments. [INDIGO Catalog Nos. IB04001-32 IB04001 IB04002]
Cayman Chemical 7-MethylgunIn 50mg
A reversible inhibitor of serine proteases such as trypsin (Ki 0.06 pM) chymotrypsin (Ki 9.5 nM) and kallikrein (Ki 0.8 nM) widely used as a protein purification tool to prevent proteases present in tissue samples from degrading the protein of interest
Cayman Chemical 2AmInopurInhydrochLRIde 100mg
A highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki 80 pM) inhibits the H3K79 methylation in various human leukemia cell lines (IC50s 3-5 nM) decreasing MLL-fusion target gene expression and inhibiting proliferation intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia
Cayman Chemical DobutamInhydrochlorIde 50mg
An OEA analog that stimulates PPARa transcriptional activity (EC50 100 nM) and prolongs feeding latency in rodents (ED50 2.4 mg/kg) as potent as OEA yet resistant to enzymatic hydrolysis demonstrates weak affinity for the CB1 and CB2 receptors (Ki 33 and 26 UM respectively
Cayman Chemical MetoprololsuccInate 50mg
A potent selective and orally active inhibitor of human mPGES-1 (IC50 1.3 nM) potently inhibits guinea pig mPGES-1 (IC50 0.9 nM) but not mouse or rat mPGES-1 prevents LPS-induced pyresis hyperalgesia and iodoacetate-induced osteoarthritic pain
Cayman Chemical FInasterIde 100mg
An L-type calcium channel blocker reduces amplitude of spontaneous contractions in isolated rabbit ileum at 1 M reduces TGF-b-induced calcium oscillations in human fibroblasts at 1 M prevents impairment of lung function in a mouse model of bleomycin-induced pulmonary fibrosis at 10 mg/kg per day reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats at 10 g/kg
Cayman Chemical 1Methyl4ImIdazoleACtIc Ac 50mg
A potential metabolite produced during metabolism of AB-CHMINACA in the liver intended for forensic and research applications
Cayman Chemical DetomIdInhydrochlorIde 100mg
An odoriferous component of musk that has been shown to exhibit anti-inflammatory effects by reducing the expression of proinflammatory cytokines both in vitro and in vivo also reported to be both cardioprotective and neuroprotective during conditions of ischemia and to promote proliferation and differentiation of neural stem cells
Cayman Chemical TrIamcInolon acetonIde 100mg
An orally active direct inhibitor of Factor Xa (Ki 0.4 nM) that inhibits thrombin formation without prolonging bleeding time approved for clinical use as an anticoagulant in the prevention of stroke and the treatment of venous thromboembolisms
Cayman Chemical D-Mnoheptulose 50mg
An antiemetic and NK1 antagonist (Ki 3 nM IC50 0.09 nM for the human receptor) selective for NK1 over NK3 receptors (Ki 454.1 nM for human NK3) prevents substance P-induced plasma extravasation into the esophagus of guinea pigs at 1 mg/kg reduces NK1-agonist-induced foot tapping in gerbils