Human Sera
Cayman Chemical 4fluoroaPyrrolIdInopropIo 50mg
A derivative of α-PPP, characterized by the addition of a fluorine group at the 4 position of the phenyl ring; intended for forensic and research applications
Cayman Chemical 5a-ndrost-2-en-17-on 50mg
A steroid; an intermediate in the synthesis of steroids and pipecuronium bromide
Cayman Chemical GlycochenodeoxycholIc ACD 50mg
A glycine-conjugated form of chenodeoxycholic acid; reduces formation of cholic acid in primary human hepatocytes at 100 µM; reduces the number LC3 puncta and is cytotoxic to L-02 hepatocytes at 50, 75, and 100 µM; induces apoptosis in isolated rat hepatocytes at 50 µM; fecal levels are decreased in a rat model of high-fat diet-induced obesity compared with rats fed a normal diet
American Research Products Inc Human high risk papillomaVirus
Human high risk papillomaVirus L1-capsids (HR-HPVL1) antibody (IgG) ELISA kit from CUSABIO Detection Range Sensitivity Sample serum plasma Method Indirect
Cayman Chemical ClotrImazole 50mg
An imidazole antifungal; tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane; inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively) in mammalian cells
Cayman Chemical LevosImendn 100mg
A calcium sensitizer that causes increased cardiac contractility by binding troponin C (EC50 = 9 nM), promotes vasodilation by activating ATP-sensitive potassium channels on vascular smooth muscle cells (EC50 = 0.28 µM), and performs a cardioprotective function by prompting the opening of mitochondrial potassium channels in cardiomyocytes; also inhibits phosphodiesterases 3 and 4 (IC50s =2.5 nM and 25 µM, respectively)
Cayman Chemical MIdodrInhydrochlorIde 100mg
A prodrug form of desglymidodrine; increases MAP and decreases heart rate in normotensive rats at 5 mg/kg
Cayman Chemical EmpaglIflozIn 50mg
An SGLT2 inhibitor (IC50 = 3.1 nM for the human transporter); reduces non-fasting blood glucose levels, as well as aortic superoxide levels and cardiac interstitial fibrosis, in db/db mice when administered in the diet at 0.03%; decreases the severity of glomerulosclerosis, as well as reduces the escape latency in the Morris water maze, in the same model
Cayman Chemical In vItro Screeng for DrugI 96
A RIPK1 inhibitor (IC50s 16 and 2500 nM for the human and mouse enzymes respectively) 10000-fold selective for RIPK1 over a panel of 339 kinases at 10 UM inhibits necrotic cell death induced by a combination of TNF-a and the caspase inhibitor QVD-OPh in U937 human monocytic and L929 murine fibrosarcoma cells (IC50s 6 3 and 1300 nM respectively) decreases IL-1B and IL-6 levels in intestinal mucosa tissue isolated from patients with ulcerative colitis at 3-300 nM increases survival in a mouse model of TNF-a-induced lethal shock at 3 10 and 50 mg/kg
Cayman Chemical Ppequaln 50mg
A partial agonist of central benzodiazepine receptors (Ki = 78 nM in a radioligand binding assay); potentiates muscle relaxant and hypnotic effects of diazepam in mice; increases drinking in the Vogel punished drinking task indicating anxiolytic-like activity
Cayman Chemical TolbutamIde 100mg
A SUR1/Kir6.2 channel inhibitor (IC50 = 4.9 µM); selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively); increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets; reduces blood glucose levels in a mouse model of STZ-induced diabetes at 80 mg/kg
Cayman Chemical trcetrapb 50mg
A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg
Cayman Chemical TAS 103hydrochlorIde 100mg
A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models